Deck 16: Treatment of Osteoporosis and Pagets Disease of the Bone

Question 1

Vitamin _____ enhances calcium absorption and is one of the hormones involved in the formation of osteoclasts.

A)A
B)B
C)C
D)D

Answer 1

D
Vitamin D enhances calcium absorption and is one of the hormones involved in the formation of osteoclasts.

Question 2

The precursor to osteoporosis is ______.

A)osteoblastosis
B)osteopenia
C)osteosarcoma
D)osteoma

Answer 2

B
Osteopenia is a condition whereby bone mineral density is decreased and is the precursor of osteoporosis.

Question 3

MATCHING
Match the following trade and generic drug names
a.raloxifene
b.etidronate
c.alendronate
d.zoledronic acid
e.pamidronate
Didronel

Answer 3

B

Question 4

The bone cells osteoblasts are responsible for _____.

A)bone formation
B)deposition of the collagen matrix of bone
C)mineralization of the collagen matrix of bone
D)all of the above

Question 5

Which of the following is not a pharmacological treatment goal for osteoporosis?

A)increase bone density
B)prevent all fractures from happening
C)reduce risks for future fractures.
D)decrease the formation of bone

Question 6

The majority of the drugs used to treat osteoporosis and Paget's disease are antiresorptive agents.Which one of the following classifications is not an antiresorptive agent?

A)bisphosphonates
B)bicarbonates
C)calcitonin
D)estrogens

Question 7

Paget's disease is most common in which sex and age group?

A)women over 55 years of age
B)men over 55 years of age
C)women over 70 years of age
D)men over 70 years of age

Question 8

Raloxifene,a selective estrogen receptor modulator,is indicated for the treatment and prevention of osteoporosis in _____ women.

A)perimenopausal
B)menopausal
C)postmenopausal
D)all of the above

Question 9

Calcium _____ is most absorbable and easiest to tolerate.

A)carbonate
B)citrate
C)gluconate
D)chloride

Question 10

How do parathyroid hormone analogs work to treat osteoporosis?

A)increase the rate of bone remodeling
B)thicken structural units of bone (ostens)
C)produce bone architecture that closely resembles normal bone
D)all of the above

Question 11

A chronic,progressive disease of bone characterized by loss of bone density and bone strength and resulting in increased fracture risk is called _____.

A)rheumatoid arthritis
B)osteoporosis
C)brittle bone disease
D)osteosarcoma

Question 12

Bisphosphonates must be taken on an empty stomach,at least _____ before the first meal or beverage of the day.

A)20 minutes
B)30 minutes
C)1 hour
D)It does not matter.

Question 13

What can be the extent of damage of Paget's disease on the body?

A)widespread throughout the body
B)entire skeleton may be affected
C)affects only joints
D)a and b

Question 14

Fractures caused by osteoporosis are classified as _____.

A)low-impact fractures
B)fragility fractures
C)spinal fractures
D)a and b

Question 15

Bisphosphonates work by _____.

A)inhibiting osteoblast activity
B)interfering with recruitment,differentiation,and action of osteoclasts
C)inhibiting osteoclast activity
D)b and c

Question 16

Which of the following drugs in not a nitrogen-containing bisphosphonate?

A)etidronate
B)alendronate
C)risedronate
D)pamidronate

Question 17

MATCHING
Match the following trade and generic drug names
a.raloxifene
b.etidronate
c.alendronate
d.zoledronic acid
e.pamidronate
Fosamax

Question 18

Of the following substances of abuse,which one can produce osteoporosis?

A)cocaine
B)alcohol
C)smoking
D)none of the above

Question 19

Which of the following hormones is not responsible for regulation of serum calcium levels?

A)parathyroid hormone
B)calcitonin
C)vitamin E
D)vitamin D

Question 20

Pharmacotherapy guidelines for osteoporosis are based on _____.

A)lowered levels of calcium
B)decrease in osteoclasts
C)extent of bone loss
D)increase in osteoclasts

Question 21

MATCHING
Match the following trade and generic drug names
a.raloxifene
b.etidronate
c.alendronate
d.zoledronic acid
e.pamidronate
Aredia

Question 22

MATCHING
Match the following trade and generic drug names
a.raloxifene
b.etidronate
c.alendronate
d.zoledronic acid
e.pamidronate
Evista

Question 23

MATCHING
Match the following trade and generic drug names
a.raloxifene
b.etidronate
c.alendronate
d.zoledronic acid
e.pamidronate
Zometa