Deck 3: Characteristics and Applications of Controlled Drug Release Systems

Question 1

Which of the following is true for monolithic devices?

A)These devices are used when the drug permeation rate is rapid
B)The release of the drug is controlled
C)Suitable for drugs with large therapeutic indices
D)The drug is contained in a powder form floating on liquid

Answer 1

Suitable for drugs with large therapeutic indices

Question 2

The duration of action of parental controlled release systems can be extended up to what time?

A)1 day
B)1 week
C)1 month
D)Day, week, month even a year

Answer 2

Day, week, month even a year

Question 3

What is the drawback of parental controlled release systems?

A)Injecting is a difficulty
B)The drug cannot be easily removed once administered
C)Can get easily precipitated in the injection site
D)Rapid onset but fast excretion

Answer 3

The drug cannot be easily removed once administered

Question 4

Which one of the following should not be a characteristic of the vehicles or polymers which are used for parenteral formulations?

A)Sterile
B)Consists of pyrogen
C)Nonirritating
D)Biodegradable

Question 5

With aqueous solutions, the drug releases can be controlled. Which of the following is not the right method of controlling?

A)Increasing the viscosity
B)By forming complexes with macromolecules
C)Reducing the solubility of the parent drug
D)Increasing the pH to make it highly basic

Question 6

Release of water-soluble drugs can be retarded by presenting it as ____________ suspension

A)Oil
B)Water
C)Colloidal
D)Freezing

Question 7

Larger particle size leads to ____________ dissolution

A)Slower
B)Faster
C)Moderate
D)Normal

Question 8

Which of the following is a characteristic of microspheres?

A)Free flowing powders
B)Aqueous solutions
C)Control drug release by partitioning the drug from the oil
D)Administration of emulsions

Question 9

Which of the following is a characteristic of oil solutions?

A)Free flowing powders
B)Aqueous solutions
C)Control drug release by partitioning the drug from the oil
D)Administration of emulsions

Question 10

Which of the following is a characteristic of aqueous solutions?

A)Free flowing powders
B)Drug release can be increased by increasing viscosity
C)Control drug release by partitioning the drug from the oil
D)Administration of emulsions

Question 11

Which of the following is a characteristic of nanoparticles?

A)Free flowing powders
B)Aqueous solutions
C)Control drug release by partitioning the drug from the oil
D)Size range 10-100 nm

Question 12

Which of the following is a characteristic of the parental controlled drug release system by liposomes?

A)Free flowing powders
B)Aqueous solutions
C)Lipid bilayer enclosing the drug
D)Administration of emulsions

Question 13

Which of the following can be incorporated into a liposome?

A)Only drugs and viruses
B)Only Peptides and viruses due to similar characteristics
C)Only viruses
D)Drugs, peptides, viruses, bacteria

Question 14

Which of the following is a characteristic of resealed erythrocytes?

A)Nonimmunogenic
B)Aqueous solutions
C)Control drug release by partitioning the drug from the oil
D)Size range 10-100 nm

Question 15

Which of the following statement is false for osmotic pumps?

A)The pump has three concentric circle
B)The innermost is the drug reservoir
C)The drug is contained a permeable polyester bag
D)Outer most rigid rate controlling semipermeable membrane

Question 16

Which of the following statement is true for osmotic pumps?

A)The tube is made up of stainless steel
B)The innermost is the drug reservoir in a no collapsible bag
C)The drug is contained a permeable polyester bag
D)The outer most cover is soft and easily permeable

Question 17

Which of the following should not be a property of implants?

A)Environmental stable
B)Biostable
C)Non-toxic
D)Nonremovable

Question 18

Which is the disadvantage for implants?

A)More effective
B)More prolonged action
C)Significantly small dose
D)Need of microsurgery

Question 19

Subcutaneous tissue is an ideal location for implants?

Question 20

Which of the following drugs are used in implants?

A)Pantoprazole
B)Mannitol
C)Amlodipine
D)Morphine antagonist

Question 21

Which of the following is a false statement for vapour pressure pump?

A)The device consists of two chambers
B)A chamber contains the drug solution
C)Drug solution chamber is separated by rigid walls
D)Vapour chamber contains vaporizable fluids

Question 22

After implantation of a vapour pressure pump, the body has to get heated by exercising so that the
volatile liquid vaporizes.

Question 23

Which of the following is a characteristic of battery powered pumps?

A)Free flowing powders
B)The system is programmed to release drugs at a controlled rate
C)Control drug release by partitioning the drug from the oil
D)Administration of emulsions

Question 24

The drug loading in resealed erythrocytes can be done by 1st immersing the cells in a buffered
hypertonic solution.

Question 25

How are MLV liposomes made?

A)2-10 bilayers of lipid
B)Series of concentric bilayers of lipid
C)The single bilayer of lipid
D)100 bilayer of lipid

Question 26

How are OLV liposomes made?

A)2-10 bilayers of lipid
B)Series of concentric bilayers of lipid
C)A single bilayer of lipid
D)100 bilayer of lipid