Deck 4: Pharmacology and Drug Therapy

Question 1

Low molecular weight heparins differ from unfractionated heparin in that:

A)They selectively inhibit factor Xa
B)They do not significantly prolong clotting time
C)They are metabolized slowly and have longer duration of action
D)All of the above are correct

Answer 1

All of the above are correct

Question 2

Low molecular weight heparins have the following advantages over unfractionated heparin except:

A)Higher efficacy in arterial thrombosis
B)Less frequent dosing
C)Higher and more consistent subcutaneous bioavailability
D)Laboratory monitoring of response not required

Answer 2

Higher efficacy in arterial thrombosis

Question 3

Choose the drug of which IUPAC name is 1,1-dimethylbiguanide.

A)Glipizide
B)Metformin
C)Pioglitazone
D)Tolbutamide

Answer 3

Metformin

Question 4

Which fibrinolytic agent(s) selectively activate(s) fibrin bound plasminogen rather than circulating plasminogen:

A)Urokinase
B)Streptokinase
C)Alteplase
D)Both 'A' and 'C'

Question 5

The most important complication of streptokinase therapy is:

A)Hypotension
B)Bleeding
C)Fever
D)Anaphylaxis

Question 6

Aspirin prolongs bleeding time by inhibiting the synthesis of:

A)Clotting factors in liver
B)Prostacyclin in vascular endothelium
C)Cyclic AMP in platelets
D)Thromboxane A2 in platelets

Question 7

The following is true of clopidogrel except:

A)It is a GPIIb/IIIa receptor antagonist
B)It inhibits fibrinogen induced platelet aggregation
C)It is indicated for prevention of stroke in patients with transient ischaemic attacks
D)It is a prodrug

Question 8

Choose the most potent and most efficacious LDL cholesterol lowering HMG-CoA reductase inhibitor:

A)Lovastatin
B)Simvastatin
C)Pravastatin
D)Atorvastatin

Question 9

Select the most appropriate hypolipidemic drug for a patient with raised LDL-cholesterol level but normal triglyceride level:

A)A HMG-CoA reductase inhibitor
B)A fibric acid derivative
C)Gugulipid
D)Nicotinic acid

Question 10

Select the hypolipidemic drug that enhances lipoprotein synthesis, fatty acid oxidation and LDLreceptor expression in liver through paroxisome proliferator-activated receptor ?

A)Lovastatin
B)Atorvastatin
C)Bezafibrate
D)Nicotinic acid

Question 11

Plasma expanders are used in the following conditions except: (Note: They will increase circulating blood volume and thus preload on heart, which will worsen heart failure.)

A)Congestive heart failure
B)Extensive burns
C)Mutilating injuries
D)Endotoxin shock

Question 12

Trapping of iodide by the following organ/organs is enhanced by thyrotropin:

A)Thyroid
B)Salivary gland
C)Placenta
D)All of the above

Question 13

Triiodothyronine differs from thyroxine in that:

A)It is more avidly bound to plasma proteins
B)It has a shorter plasma half life
C)It is less potent
D)It has a longer latency of action

Question 14

The most reliable guide to adjustment of thyroxine dose in a patient of hypothyroidism is:

A)Pulse rate
B)Body weight
C)Serum thyroxine level
D)Serum TSH level

Question 15

Actions of thyroxine include the following except:

A)Induction of negative nitrogen balance
B)Reduction in plasma cholesterol level
C)Fall in plasma free fatty acid level
D)Rise in blood sugar level

Question 16

acts by inhibiting:

A)Iodide trapping
B)Oxidation of iodide
C)Proteolysis of thyroglobulin
D)Synthesis of thyroglobulin protein

Question 17

Antithyroid drugs exert the following action:

A)Inhibit thyroxine synthesis
B)Block the action of thyroxine on pituitary
C)Block the action of TSH on thyroid
D)Block the action of thyroxine on peripheral tissues

Question 18

Given structure is of

A)Propyl thiouracil
B)Methimazole
C)Carbimazole
D)Radioactive iodine

Question 19

The following thyroid inhibitor interferes with peripheral conversion of thyroxine to triiodothyronine:

A)Propyl thiouracil
B)Methimazole
C)Carbimazole
D)Radioactive iodine

Question 20

The uses of sodium/potassium iodide include the following except:

A)Preoperative preparation of Grave's disease patient
B)Prophylaxis of endemic goiter
C)As antiseptic
D)As expectorant

Question 21

The physical half life of radioactive 131I is:

A)8 hours
B)8 days
C)16 days
D)60 days

Question 22

Propranolol is used in hyperthyroidism:

A)As short-term symptomatic therapy till effect of carbimazole develops
B)As long-term therapy after subtotal thyroidectomy
C)In patients not responding to carbimazole
D)To potentiate the effect of radioactive iodine

Question 23

Insulin release from pancreatic ? cells is augmentednby the following except:

A)Ketone bodies
B)Glucagon
C)Vagal stimulation
D)Alfa adrenergic agonists

Question 24

Action of Insulin does not include the following:

A)Facilitation of glucose transport into cells
B)Facilitation of glycogen synthesis by liver
C)Facilitation of neoglucogenesis by liver
D)Inhibition of lipolysis in adipose tissue

Question 25

The major limitation of the thiazolidinediones in the treatment of type 2 diabetes mellitus is:

A)Frequent hypoglycaemic episodes
B)Hyperinsulinemia
C)Lactic acidosis
D)Low hypoglycaemic efficacy in moderate to severe cases