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Biochemistry 6th Edition by Reginald Garrett,Charles Grisham
Edition 6ISBN: 978-1305577206Biochemistry 6th Edition by Reginald Garrett,Charles Grisham
Edition 6ISBN: 978-1305577206 Exercise 12
Vitamins and coenzymes in branched-chain amino acid degradation
(Integrates with Chapter 19.) On the basis of the following information, predict a reaction mechanism for the mammalian branched-chain ?-keto acid dehydrogenase complex (the BCKAD complex). This complex carries out the oxidative decarboxylation of the ?-keto acids derived from valine, leucine, and isoleucine.
a. One form of maple syrup urine disease responds well to administration of thiamine.
b. Lipoic acid is an essential coenzyme.
c. The enzyme complex contains a flavoprotein.
(Integrates with Chapter 19.) On the basis of the following information, predict a reaction mechanism for the mammalian branched-chain ?-keto acid dehydrogenase complex (the BCKAD complex). This complex carries out the oxidative decarboxylation of the ?-keto acids derived from valine, leucine, and isoleucine.
a. One form of maple syrup urine disease responds well to administration of thiamine.
b. Lipoic acid is an essential coenzyme.
c. The enzyme complex contains a flavoprotein.
Explanation
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When we see thiamine, lipoic acid and fl...
Biochemistry 6th Edition by Reginald Garrett,Charles Grisham
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