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Molecular Biology 5th Edition by Robert Weaver
Edition 5ISBN: 978-0073525327Molecular Biology 5th Edition by Robert Weaver
Edition 5ISBN: 978-0073525327 Exercise 3
You are studying a eukaryotic gene in which translation normally begins with the second AUG in the mRNA. The sequence surrounding the two AUG codons is:
CGG AUG CACAGGACAUCCUAUGGAG AUG A
where the two AUG codons are underlined. Predict the effects of the following mutations on translation of this mRNA.
a. Changing the fi rst and second C's to G's.
b. Changing the fi rst and second C's to G's, and also changing the UAU codon before the second AUG codon to UAG.
c. Changing the GAG AUG A sequence at the end to CAG AUG U
CGG AUG CACAGGACAUCCUAUGGAG AUG A
where the two AUG codons are underlined. Predict the effects of the following mutations on translation of this mRNA.
a. Changing the fi rst and second C's to G's.
b. Changing the fi rst and second C's to G's, and also changing the UAU codon before the second AUG codon to UAG.
c. Changing the GAG AUG A sequence at the end to CAG AUG U
Explanation
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The genetic message on the mRNA is read ...
Molecular Biology 5th Edition by Robert Weaver
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