Urinalysis and Body Fluids 6th Edition by Majorie DiLorenzo, Susan Strasinger

Exercise 32

Deficiency of the GALT enzyme will produce a:

A. Positive Clinitest

B. Glycosuria

C. Galactosemia

D. Both A and C

Step 1 of 2

GALT (galactose -1-phosphate uridyl transferase):

• GALT galactose -1-phosphate uridyl transferase is helpful in conversion of consumed galactose to glucose

• This enzyme deficiency causes fatal symptoms related with galactosemia

• Deficiency of GALT enzyme produces positive clinitest, because galactose level is increased in body leading to its excretion in urine

Galactosemia:

• It is metabolic disorder have autosomal recessive type of inheritance, which leads to deficiency of enzyme, which helps in galactose degradation

• Galactosemia with intermediate metabolic products causes liver disorders, mental retardation, and cataract in infants

• Newborn screening is available for the presence of GALT galactose -1-phosphate uridyl transferase deficiency

Therefore, deficiency of GALT enzyme will produce “positive Clinitest”, and “galactosemia”. Hence, the correct answer is option.