Urinalysis and Body Fluids 6th Edition by Majorie DiLorenzo, Susan Strasinger

Exercise 24

The highest levels of proteinuria are seen with:

A. Alport syndrome

B. Diabetic nephropathy

C. IgA nephropathy

D. Nephrotic syndrome

Step 1 of 2

Nephrotic syndrome:

• Nephrotic syndrome is indicated by proteinuria (more than 3.5 grams per day), low serum albumin level, high serum lipid level and edema

• Glomerular membrane’s increased permeability causes damage to shield of negativity and to podocytes (less tightly connected barrier).

• This damage facilitates negatively charged albumin, high -molecular -weight proteins and lipid passage into urine.

• Urinalysis observation shows oval fat bodies, fat droplets, renal tubular epithelial cell, fatty casts, epithelial casts, waxy casts, and microscopic hematuria.

Therefore, presence of highest level of proteinuria is seen with “nephrotic syndrome”. Hence, the correct answer is option .