Urinalysis and Body Fluids 6th Edition by Majorie DiLorenzo, Susan Strasinger

Exercise 23

Relate laboratory results associated with the nephrotic syndrome to the disease process.

Step 1 of 2

Nephrotic syndrome is indicated by proteinuria (more than 3.5 grams per day), low serum albumin level, high serum lipid level and edema

• Glomerular membrane’s increased permeability causes damage to shield of negativity and to podocytes (less tightly connected barrier).This damage facilitates negatively charged albumin, high-molecular-weight proteins and lipid passage into urine

• Urinalysis observation shows oval fat bodies, fat droplets, renal tubular epithelial (RTE) cells, fatty casts, epithelial casts, waxy casts, and microscopic hematuria