Urinalysis and Body Fluids 6th Edition by Majorie DiLorenzo, Susan Strasinger

Exercise 15

Antineutrophilic cytoplasmic antibody is diagnostic for:

A. IgA nephropathy

B. Wegener granulomatosis

C. Henoch-Schönlein purpura

D. Goodpasture syndrome

Step 1 of 2

Wegener granulomatosis:

It is a condition of granuloma causing inflammation in small blood vessels of respiratory and kidney system.

• Binding of antineutrophilic cytoplasmic auto antibody to neutrophils of vascular walls stimulates immune response, finally granuloma formation.

• Patients are seen with pulmonary symptoms first and then develops renal symptoms such as proteinuria, RBC (Red Blood Cell) casts, hematuria and high serum creatinine.

• Diagnosis of wegener granulomatosis is done with antineutrophilic cytoplasmic auto antibody in the serum of patient.

Therefore, “Wegener granulomatosis” is diagnosed with antineutrophilic cytoplasmic auto antibody. Hence, the correct answer is option .