Urinalysis and Body Fluids 6th Edition by Majorie DiLorenzo, Susan Strasinger

Exercise 7

A physician would like to prescribe a nephrotoxic antibiotic for a 60-year-old Caucasian man. The patient has a

serum creatinine level of 1.5 mg/dL.

a. How can the physician determine whether it is safe to prescribe this medication before the patient leaves the office?

b. State two additional blood tests that the physician could use to continue monitoring this patient.

c. If the patient has a history of prostate malignancy,would both of these methods provide reliable results? Explain your answer.

Step 1 of 4

a.

Physician calculates creatinine clearance with the help of MDRD-IDSM traceable formula.

Creatinine clearance test:

Creatinine is formed by creatine by the enzyme creatinine phosphokinase.

• Muscle metabolism produces creatinine as a waste product

• This creatinine is utilized to calculate filtering ability of glomeruli in laboratory

Modification of Diet in Renal Disease-Isotope Dilution Mass Spectrophotometry (MDRD-IDSM):

• Formula to compute GFR is MDRD-IDSM

• The formula is given below,

Where,

GFR- Glomerulus Filtration Rate