If a mutation were to occur to disrupt the localization of ankyrinG, such that this protein became distributed throughout the Purkinje cell body and axon, what phenotype would you expect? Briefly explain your reasoning, assuming that the mutation does not disrupt interactions between ankyrinG and neurofascin.

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Quizplus · Accepted Answer

The Answer is Neurofascin would still associate with the ankyrinG, causing it to be diffusely distributed and resulting in the overshooting and abnormal branching of basket cell axon terminals.

If a Mutation Were to Occur to Disrupt the Localization