In a person with cystic fibrosis, the CFTR mutation causes the protein to be ____.
A) embedded in the plasma membrane
B) destroyed in the endoplasmic reticulum
C) shuttled to the nuclear membrane instead of the plasma membrane
D) shuttled to the plasma membrane instead of the nuclear membrane
E) expelled from the cell by exocytosis before it can do its job

Question

In a person with cystic fibrosis, the CFTR mutation causes the protein to be ____.​
A) ​embedded in the plasma membrane
B) ​destroyed in the endoplasmic reticulum
C) ​shuttled to the nuclear membrane instead of the plasma membrane
D) ​shuttled to the plasma membrane instead of the nuclear membrane
E) ​expelled from the cell by exocytosis before it can do its job

Quizplus · Accepted Answer

The CFTR mutation in cystic fibrosis often leads to the protein being misfolded, which is recognized by the cell's quality control mechanisms. As a result, the misfolded protein is typically destroyed in the endoplasmic reticulum before it can be transported to the plasma membrane, where it would normally function to regulate chloride ion transport.

In a Person with Cystic Fibrosis, the CFTR Mutation Causes