Suppose there is a mutation in a laminin-binding integrin gene that causes a loss of function in the cytoplasmic domains of the integrin. Which of the following would you expect to observe as a result of this mutation?
A)The integrin would be unable to signal the cytoplasm when it had bound to laminin.
B)The integrin would function normally because the cytoplasmic domain is not responsible for binding to laminin.
C)Tissues would be weakened because the integrin could no longer associate with microfilaments in adherens junctions.
D)Cell adhesion to laminin would decrease, but laminin-meditated gene expression would remain the same.

Question

Quizplus · Accepted Answer

The cytoplasmic domain is responsible for transmitting signals from the outside of the cell to the inside. If this domain is non-functional, then the integrin would be unable to signal the cytoplasm when it had bound to laminin.

Suppose There Is a Mutation in a Laminin-Binding Integrin Gene