Which statement about the PiZ allele is NOT true? Consult Figure 15.2 below.
A)The PiZ allele is common in populations of European descent.
B)The product of nonmutant alleles of the gene inhibits elastase in the lungs.
C)Individuals homozygous for the PiZ allele have normal lung elasticity.
D)Normal lung elasticity depends on elastase inhibition.
E)Smokers who are homozygous for the PiZ allele have a shortened life expectancy.

Question

Which statement about the PiZ allele is NOT true? Consult Figure 15.2 below. 
A)The PiZ allele is common in populations of European descent. 
B)The product of nonmutant alleles of the gene inhibits elastase in the lungs. 
C)Individuals homozygous for the PiZ allele have normal lung elasticity. 
D)Normal lung elasticity depends on elastase inhibition. 
E)Smokers who are homozygous for the PiZ allele have a shortened life expectancy.

Quizplus · Accepted Answer

Individuals homozygous for the PiZ allele have impaired lung function and reduced lung elasticity. The PiZ allele is a rare mutation that affects the production of the alpha-1 antitrypsin protein, which helps to inhibit elastase in the lungs. The normal function of elastase inhibition is necessary for maintaining healthy lung tissue. Individuals who are homozygous for the PiZ allele have reduced levels of alpha-1 antitrypsin, which allows elastase to attack lung tissue, leading to chronic obstructive pulmonary disease (COPD) and emphysema. The PiZ allele is most commonly found in populations of European descent. Smokers who are homozygous for the PiZ allele are at increased risk for developing these conditions and have a shortened life expectancy.

Which Statement About the PiZ Allele Is NOT True? Consult