What statement is NOT true regarding retroviral reverse transcriptase and eukaryotic DNA polymerase $\delta$ ?
A) Both enzymes require nucleic acid templates.
B) Both enzymes include proof-reading functions.
C) Both enzymes use dNTPs as substrates for synthesis.
D) Both enzymes require metal cofactors.
E) All of the statements are true.

Question

What statement is NOT true regarding retroviral reverse transcriptase and eukaryotic DNA polymerase  $\delta$ ?
A) Both enzymes require nucleic acid templates.
B) Both enzymes include proof-reading functions.
C) Both enzymes use dNTPs as substrates for synthesis.
D) Both enzymes require metal cofactors.
E) All of the statements are true.

Quizplus · Accepted Answer

Retroviral reverse transcriptase lacks a proof-reading function, which is present in eukaryotic DNA polymerase. This leads to a higher mutation rate in viruses using reverse transcriptase.

What Statement Is NOT True Regarding Retroviral Reverse Transcriptase and Eukaryotic