Each subset of effector T cells produces a distinct array of secreted factors known as cytokines. One common feature of nearly all effector T cell responses is the rapid production of increased numbers of macrophages, granulocytes, and dendritic cells from the bone marrow. This response occurs due to:
A) Effector T cell trafficking to the bone marrow to activate hematopoietic progenitor cells
B) Depletion of peripheral myeloid cells after leaving the blood, leading to increased bone marrow production
C) Inflammation-induced blood vessel dilation causing transient reductions in circulating myeloid cells
D) Pathogen-induced migration of tissue-resident dendritic cells to lymph nodes inducing new dendritic cell production
E) Effector T cell production of GM-CSF that traffics to the bone marrow

Question

Quizplus · Accepted Answer

Effector T cells can produce granulocyte-macrophage colony-stimulating factor (GM-CSF), which can stimulate bone marrow to produce more myeloid cells. Therefore, effector T cells can indirectly induce an increase in the number of macrophages, granulocytes, and dendritic cells through their production of GM-CSF.

Each Subset of Effector T Cells Produces a Distinct Array