The dimethoxytrityl (DMTr) group protects which functional group during synthetic DNA synthesis?
A) the primary amine group of adenine and guanine
B) the primary amine group of cytosine
C) the 3' hydroxyl of the deoxyribose
D) the 5' hydroxyl of the deoxyribose
E) both A and B are correct

Question

Quizplus · Accepted Answer

The dimethoxytrityl (DMTr) group is used to protect the 5' hydroxyl group of the deoxyribose sugar during the chemical synthesis of DNA, preventing unwanted reactions at this site.

The Dimethoxytrityl (DMTr) Group Protects Which Functional Group During Synthetic