Which of the following statements regarding inhibitors is correct? A) a transition state analog binds covalently to the enzyme B) a non-competitive inhibitor causes an increase in the V_max C) the presence of a competitive inhibitor can be overcome by addition of more inhibitor D) a competitive inhibitor results in a higher apparent K_m value E) none of the above are correct

Question

Quizplus · Accepted Answer

A competitive inhibitor results in a higher apparent Km value, which means the enzyme has a decreased affinity for the substrate. Choice A is incorrect because a transition state analog mimics the transition state of the catalyzed reaction, not binding covalently. Choice B is incorrect because a non-competitive inhibitor does not affect the Km value. Choice C is incorrect because adding more inhibitor would only further compete with the substrate for binding, resulting in more inhibition.

Which of the Following Statements Regarding Inhibitors Is Correct