Which of the following would cause an increase in the conversion of IMP to GMP?
A) high levels of CMP
B) high levels of dTTP
C) high levels of UMP
D) high levels of AMP
E) none of the above

Question

Quizplus · Accepted Answer

IMP can be converted into GMP through the IMP dehydrogenase (IMPDH) pathway. High levels of AMP can activate AMP-activated protein kinase (AMPK) which, in turn, phosphorylates and activates IMPDH, leading to an increase in the conversion of IMP to GMP. Therefore, high levels of AMP would cause an increase in the conversion of IMP to GMP.

Which of the Following Would Cause an Increase in the Conversion