Huge multi-subunit entities that mediate ATP-dependent conformational changes that peel 50bp of DNA from the edge of nucleosome core particles and create a "bulge" in the DNA:core nucleosomes association are called:
A) histone deacetylase complexes (HDACs).
B) DNA-bound transcriptional activators.
C) chromatin-remodeling complexes .
D) general transcriptional factors (GTFs).
E) all are true.

Question

Quizplus · Accepted Answer

The description is consistent with chromatin-remodeling complexes, which are multi-subunit entities that can alter the structure of chromatin. Specifically, they can move nucleosomes along DNA, remove nucleosomes, or alter the conformation of nucleosomes to facilitate DNA access by transcriptional machinery. Histone deacetylase complexes (HDACs) can also modify chromatin structure, but this question is more specifically describing a mechanism involving physical changes to the DNA:nucleosome association. DNA-bound transcriptional activators and general transcriptional factors (GTFs) are involved in gene expression, but they do not directly manipulate the structure of chromatin.

Huge Multi-Subunit Entities That Mediate ATP-Dependent Conformational Changes That Peel