What is the major signaling molecule that binds to soluble guanylate cyclase?
A) cAMP
B) Epinephrine
C) Glucagon
D) Insulin
E) NO

Question

Quizplus · Accepted Answer

The major signaling molecule that binds to soluble guanylate cyclase is nitric oxide (NO). NO is produced by endothelial cells and diffuses into the smooth muscle where it binds to soluble guanylate cyclase and activates it, leading to the production of cyclic guanosine monophosphate (cGMP) and subsequent smooth muscle relaxation. This signaling pathway is important in the regulation of blood pressure and is targeted by drugs like nitroglycerin and sildenafil (Viagra).

What Is the Major Signaling Molecule That Binds to Soluble