The bulk of the sequence data in whole-genome sequencing directly comes from ________.
A) relatively large (~160 kb) sequences cloned into bacterial artificial chromosomes (BACs)
B) relatively small (~1000 base-pair) sequences cloned into plasmids
C) whole chromosomes obtained without cloning
D) whole chromosomes cloned into plasmids

Question

Quizplus · Accepted Answer

Whole-genome sequencing primarily relies on sequencing relatively small fragments (~1000 base-pair) that have been cloned into plasmids. This approach allows for the efficient sequencing of small DNA segments, which are then assembled to reconstruct the entire genome.

The Bulk of the Sequence Data in Whole-Genome Sequencing Directly