One can create a behavioral model of Parkinson disease in a rat by:
A) lesioning the substantia nigra.
B) stimulating the substantia nigra.
C) lesioning the globus pallidus.
D) stimulating the globus pallidus.

Question

Quizplus · Accepted Answer

Parkinson disease is caused by the degeneration of dopaminergic neurons in the substantia nigra, resulting in reduced dopamine levels in the striatum. Lesioning the substantia nigra in rats mimics this pathological process and produces behavioral changes similar to those observed in Parkinson patients. The other options (stimulating the substantia nigra or lesioning/stimulating globus pallidus) would not produce the same kind of Parkinson-like symptoms.

One Can Create a Behavioral Model of Parkinson Disease in a Rat