Reabsorption of nutrients like glucose and amino acids takes place in the proximal convoluted tubule (PCT)via cotransporters that utilize secondary active transport.Which of the following would stop the reabsorption of glucose at the apical surface of the cells in the PCT?
A) loss of Na+-K+ ATPase in the basolateral surface of PCT cells
B) loss of K+ leak channels at the apical surface
C) increasing Na+ concentration in the filtrate
D) increasing Na+ in the interstitial fluid

Question

Quizplus · Accepted Answer

The Na+-K+ ATPase on the basolateral surface of PCT cells is crucial for maintaining a low intracellular Na+ concentration, which drives the secondary active transport of glucose at the apical surface. Without this pump, the gradient necessary for glucose reabsorption would be lost, stopping the process.

Reabsorption of Nutrients Like Glucose and Amino Acids Takes Place