Select the best description of the negative selection process of lymphocyte maturation.
A) removal of lymphocytes that fail to recognize "self" cells
B) teaching a lymphocyte to recognize "self" from foreign antigens
C) removal of lymphocytes that react with "self" cells
D) allowing the survival of lymphocytes that cannot bind to MHC proteins

Question

Quizplus · Accepted Answer

Negative selection involves the removal of lymphocytes that react with "self" cells to prevent autoimmunity. The process is important in ensuring that only self-tolerant lymphocytes remain in circulation. Option A is not correct since it is more descriptive of positive selection. Option B is incorrect because it involves teaching instead of the elimination of cells. Option D is also incorrect since MHC proteins are important for antigen recognition and activation of T cells, and their absence would be detrimental.

Select the Best Description of the Negative Selection Process of Lymphocyte