B cells must accomplish double recognition: They must simultaneously recognize self and nonself to be activated.

Question

Quizplus · Accepted Answer

B cells recognize nonself antigens through their membrane-bound immunoglobulin receptors, but they are specifically trained to not recognize self-antigens through a process called clonal deletion. Therefore, B cells only recognize nonself antigens and do not require the ability to simultaneously recognize self and nonself.

B Cells Must Accomplish Double Recognition: They Must Simultaneously Recognize