A major difference between HTML and XML is that HTML describes the content of a page or file only in terms of how it is to be displayed and interacted with, XML describes the content in terms of what data is being included.

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HTML is primarily used for creating web pages and focuses on how the content should be presented to the user, while XML is a markup language used for storing and sharing data, with a focus on defining the structure and format of the data rather than how it should be displayed.

A Major Difference Between HTML and XML Is That HTML