To produce an allergic reaction in Type I hypersensitivity,the antigen
A)must bind to mast cells.
B)must bind to free IgE molecules.
C)must just bind to IgE on mast cells.
D)must bind to two neighboring IgE molecules on mast cells crosslinking them.

Question

Quizplus · Accepted Answer

In Type I hypersensitivity, the antigen must bind to two neighboring IgE molecules on mast cells, crosslinking them and causing degranulation of the mast cell and release of histamine and other pro-inflammatory mediators. Binding to free IgE molecules or just binding to IgE on mast cells alone without crosslinking will not produce an allergic reaction.

To Produce an Allergic Reaction in Type I Hypersensitivity,the Antigen