Which of the following is true of long-term depression (LTD)?
A) LTD is associated with an increase in the number of AMPA receptors in the postsynaptic neurons.
B) LTD reflects a gradual strengthening of synaptic connections.
C) LTD is associated with a decrease in the number of AMPA receptors in the postsynaptic neuron.
D) LTD can be produced by high-frequency stimulation of CA1 neurons.
E) LTD is not an associative phenomenon.

Question

Quizplus · Accepted Answer

LTD is associated with a decrease in the number of AMPA receptors in the postsynaptic neuron. This leads to a decrease in the strength of the synaptic connection between neurons.

Answer: D
 LTD can be produced by high-frequency stimulation of CA1 neurons, which causes a decrease in the number of AMPA receptors in the postsynaptic neuron and a subsequent weakening of the synaptic connection.

Which of the Following Is True of Long-Term Depression (LTD)