Interstitial fluid is normally hypertonic with respect to the intracellular fluid.

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Interstitial fluid is isotonic with respect to intracellular fluid in healthy individuals. This means that the concentration of solutes in the two fluids is the same, which helps to maintain the balance of water and electrolytes in the body. However, in certain disease states or conditions such as dehydration, the interstitial fluid may become hypertonic, meaning it has a higher concentration of solutes than the intracellular fluid.

Interstitial Fluid Is Normally Hypertonic with Respect to the Intracellular