What is the pathophysiologic process responsible for the autoimmune disorder of hemolytic-uremic syndrome (HUS)?
A)Immunoglobulin A (IgA) coats erythrocytes that are destroyed by the spleen, and remnants are excreted through the kidneys.
B)Verotoxin from Escherichia coli is absorbed from the intestines and damages erythrocytes and endothelial cells.
C)Endotoxins from E. coli block the erythropoietin produced by the kidneys, which reduces the number of erythrocytes produced by the bone marrow.
D)Failure of the nephron to filter urea increases the blood urea nitrogen, which binds to erythrocytes that are subsequently destroyed by the spleen.

Question

Quizplus · Accepted Answer

In HUS, verotoxin from E. coli is absorbed from the intestines, the glomerular arterioles become swollen, and these narrowed vessels damage erythrocytes as they pass through. HUS is responsible for causing a cascade of effects, including lysis of glomerular capillary endothelial cells. HUS is not caused by erythrocyte destruction, reduced erythrocytes, or an increased BUN.

What Is the Pathophysiologic Process Responsible for the Autoimmune Disorder