The summation of all IPSPs and EPSPs determines whether a postsynaptic neuron will fire.

Question

Quizplus · Accepted Answer

The summation of all inhibitory postsynaptic potentials (IPSPs) and excitatory postsynaptic potentials (EPSPs) received by a postsynaptic neuron determines whether it will reach its threshold for firing an action potential. If the combined effect of EPSPs outweighs the effect of IPSPs, the neuron will fire. If the effect of IPSPs outweighs the effect of EPSPs, the neuron will not fire. Therefore, the summation of all IPSPs and EPSPs is critical in determining the firing of a neuron.

The Summation of All IPSPs and EPSPs Determines Whether a Postsynaptic