Which of the following is TRUE regarding pituitary growth hormone (GH)?
A)The liver produces a factor that mediates the metabolic actions of GH.
B)GH stimulates insulin-like growth factor-1 (IGF-1)production by the liver and by many other cells.
C)GH increases the sensitivity of tissues to the action of insulin.
D)GH exerts negative feedback on its own production by inhibiting the hypothalamic secretion of somatostatin.
E)IGF-1 stimulates the secretion of GH by anterior pituitary gland cells.

Question

Which of the following is TRUE regarding pituitary growth hormone (GH)?
A)The liver produces a factor that mediates the metabolic actions of GH.
B)GH stimulates insulin-like growth factor-1 (IGF-1)production by the liver and by many other cells.
C)GH increases the sensitivity of tissues to the action of insulin.
D)GH exerts negative feedback on its own production by inhibiting the hypothalamic secretion of somatostatin.
E)IGF-1 stimulates the secretion of GH by anterior pituitary gland cells.

Quizplus · Accepted Answer

Pituitary growth hormone stimulates insulin-like growth factor-1 (IGF-1) production by the liver and by many other cells. IGF-1, in turn, mediates many of the anabolic effects of GH. The liver produces almost all of the circulating IGF-1 in response to GH stimulation, so measurement of serum IGF-1 is used clinically as a surrogate for GH secretion.

Which of the Following Is TRUE Regarding Pituitary Growth Hormone