The basic mechanism for short-term sensitization begins with
A)decreased neurotransmitter release.
B)increased presynaptic calcium.
C)increased expression of CREB-1.
D)increased potassium conductance.

Question

Quizplus · Accepted Answer

Short-term sensitization is initiated by the increased presynaptic calcium. This leads to the activation of protein kinases that modify the properties of ion channels and/or vesicle release machinery resulting in the enhancement of the neurotransmitter release.

Answer: C
 Although CREB-1 plays a role in long-term sensitization, it is not the initial mechanism for short-term sensitization.

The Basic Mechanism for Short-Term Sensitization Begins with