Which of the Following Statements Correctly Compares Water-Soluble Hormones with Lipid-Soluble

Which of the following statements correctly compares water-soluble hormones with lipid-soluble hormones?

A) Both types of hormone are carried in the blood attached to a carrier protein.
B) Both types of hormone almost always stimulate increases in mRNA transcription.
C) Only water-soluble hormones use second messengers.
D) Only water-soluble hormones require a receptor.
E) Lipid-soluble hormones are not found in the bloodstream.