If repeated exposure to a drug increases the activity of the CYP450 enzyme that is responsible for metabolizing that drug,then later doses will be less effective than the first few doses.This is an example of
A)drug disposition tolerance.
B)behavioral tolerance.
C)an active metabolite.
D)a prodrug.

Question

Quizplus · Accepted Answer

Drug disposition tolerance occurs when repeated exposure to a drug causes an increase in the activity of the enzymes responsible for metabolizing the drug. This can lead to decreased effectiveness of later doses as the drug is metabolized more quickly and eliminated from the body faster. This is different from behavioral tolerance, where repeated exposure to a drug can lead to a reduction in the drug's subjective effects, but without changes in its pharmacokinetics or metabolism. Active metabolites refer to compounds created when a drug is metabolized, which may have their own pharmacological effects, while prodrugs are inactive compounds that are converted to active forms through metabolism.

If Repeated Exposure to a Drug Increases the Activity of the CYP450