For what reason might the ID50 for Salmonella Typhi decrease when a rat simultaneously ingests sulfa drugs with the pathogen?
A)It would not;the ID50 goes up.
B)The antimicrobial interferes with the microbiome enabling the pathogen to more easily establish infection.
C)There would not be an effect on the ID50.
D)The antimicrobial inactivates stomach acid and allows the pathogen to more readily pass to the intestine.
E)Salmonella Typhi becomes stronger in the presence of sulfa drugs.

Question

Quizplus · Accepted Answer

Sulfa drugs can disrupt the normal microbiome of the rat's gastrointestinal tract, reducing competition for Salmonella Typhi and allowing it to more easily establish an infection. This would result in a decrease in the ID50, or the infectious dose required to cause disease in 50% of the exposed population.

For What Reason Might the ID50 for Salmonella Typhi Decrease