Identify the RBC inclusion in the following image.
A)Siderotic granule
B)Basophilic stippling
C)Howell Jolly body
D)Heinz body

Question

Identify the RBC inclusion in the following image. 
A)Siderotic granule 
B)Basophilic stippling 
C)Howell Jolly body 
D)Heinz body

Quizplus · Accepted Answer

The inclusion present in the RBCs in the given image is Howell-Jolly body. It appears as a round or oval, purple-staining structure in the RBC, which is actually a remnant of the nucleus that has not been extruded during erythropoiesis. It can be seen in certain conditions such as asplenia, megaloblastic anemia, hemolytic anemia, and after splenectomy. Siderotic granules are iron-containing granules usually seen in RBCs in conditions such as thalassemia and sideroblastic anemia. Basophilic stippling represents the aggregates of ribosomes in the RBC and usually seen in lead poisoning and thalassemia. Heinz bodies are denatured globin protein aggregates present in RBCs in certain conditions such as G6PD deficiency, alpha-thalassemia, and exposure to drugs or toxins such as aspirin and sulfonamides. None of these inclusions are seen in the given image.

Identify the RBC Inclusion in the Following Image