Garrod hypothesized that "inborn errors of metabolism" such as alkaptonuria occur because
A)genes dictate the production of specific enzymes, and affected individuals have genetic defects that cause them to lack certain enzymes.
B)enzymes are made of DNA, and affected individuals lack DNA polymerase.
C)many metabolic enzymes use DNA as a cofactor, and affected individuals have mutations that prevent their enzymes from interacting efficiently with DNA.
D)certain metabolic reactions are carried out by ribozymes, and affected individuals lack key splicing factors.
E)metabolic enzymes require vitamin cofactors, and affected individuals have significant nutritional deficiencies.

Question

Quizplus · Accepted Answer

Garrod's theory of "inborn errors of metabolism" proposed that genetic defects cause individuals to lack certain enzymes, leading to metabolic disorders. This aligns with choice A, which states that genes dictate the production of specific enzymes, and affected individuals have genetic defects that cause them to lack certain enzymes.

Garrod Hypothesized That "Inborn Errors of Metabolism" Such as Alkaptonuria