The secondary signal needed for TH0 helper cells to differentiate into either TH1 cells or TH₂ cells is the cross-link between ________ (on TH0 helper cells) and ________ (on APC cell).
A) CD154; CD40
B) MHC I; B7
C) CD4; MHC II
D) CD8; MHC I
E) CD28; B7

Question

Quizplus · Accepted Answer

CD28 on TH0 helper cells interacts with B7 on antigen-presenting cells (APCs) to provide the necessary secondary signal for differentiation into TH1 or TH2 cells.

The Secondary Signal Needed for TH0 Helper Cells to Differentiate