The activation of histone deacetylases would be expected to have which of the following effects on DNA replication?
A) decreases the rate
B) destabilizes the double-helix allowing access for polymerases
C) enhances formation of new chromatin following completion of replication
D) increases the rate
E) will have no effect on replication activity

Question

Quizplus · Accepted Answer

Histone deacetylases are responsible for changing the state of histone acetylation. The consequences of reduced histone acetylation are altered chromatin structure making it difficult for the transcriptional machinery to engage the DNA. Thus, histone deacetylation is associated with reduced transcription but does not appreciably, or at all, affect DNA replication.

The Activation of Histone Deacetylases Would Be Expected to Have