Cholestyramine is a drug used to reduce serum cholesterol. It functions through binding bile salts and thereby, interferes with normal enterohepatic circulation of bile salts in the feces. Use of this drug would be associated with increased fecal amounts of which of the following compounds?
A) bilirubin
B) cholesterol
C) deoxycholate
D) glucuronate
E) palmitate

Question

Quizplus · Accepted Answer

Cholestyramine binds bile acids like deoxycholate, preventing their reabsorption and increasing their excretion in feces.  Cholestyramine is a drug belonging to the bile-binding resin class of cholesterol-lowering drugs. These drugs function by binding bile acids in the gut, thereby, preventing their reuptake. Inhibition of bile acid uptake into the enterohepatic circulation will result in increased bile salt concentrations in the feces, including deoxycholate, a primary bile salt.

Cholestyramine Is a Drug Used to Reduce Serum Cholesterol