Defective ChREBP function would result in a reduction in the synthesis of triglycerides due to loss of the activation of the expression of which of the following genes? A) glycerol kinase B) glycerol-3-phosphate acyltransferase C) hepatic lipase D) phosphatidic acid phosphatase E) phospholipase A₂

Question

Quizplus · Accepted Answer

The Answer is B
EXPLANATION: Glycerol-3-phosphate acyltransferase (GPAT) esterifies a fatty acid to glycerol 3-phosphate generating the monoacylglycerol phosphate structure called lysophosphatidic acid. The expression of the GPAT gene is under the influence of the transcription factor ChREBP. Therefore, defective ChREBP activity would result in reduced expression of GPAT, resulting in reduced capacity to synthesize triglycerides.

Defective ChREBP Function Would Result in a Reduction in the Synthesis