Which of the following best explains why noncompetitive inhibitors of enzymes generally make better pharmaceuticals? A) their inhibitory activity is unaffected by substrate concentration B) they affect only K_m and not V_max C) they bind to the same site as the substrate D) they increase the rate of degradation of the target enzyme E) they irreversibly inhibit the enzyme

Question

Quizplus · Accepted Answer

Noncompetitive inhibitors bind to an allosteric site, not the active site, and their inhibitory effect is not influenced by substrate concentration, making them effective regardless of substrate levels.

Which of the Following Best Explains Why Noncompetitive Inhibitors of Enzymes