A deficiency in the hepatic enzyme aldolase B would result in a reduced ability to metabolize which of the following carbohydrates?
A) dihydroxyacetone
B) fructose
C) glucose
D) glyceraldehyde
E) sucrose

Question

Quizplus · Accepted Answer

Hepatic aldolase B is responsible for the hydrolysis of fructose-1-phosphate into dihydroxyacetone phosphate and glyceraldehyde. The fructose- 1-phosphate is derived via the action of ketohexokinase (fructokinase) and thus if aldolase B is deficient downstream utilization of fructose will be impaired. A deficiency in aldolase B impairs the metabolism of fructose, leading to an accumulation of fructose-1-phosphate in the liver.

A Deficiency in the Hepatic Enzyme Aldolase B Would Result