One means that researchers use in their attempt to make the groups in a study as similar as possible is to assign subjects randomly to those groups.

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Random assignment is a method used by researchers to place study participants into groups in a way that each participant has an equal chance of being in any group. This technique helps to ensure that the groups are as similar as possible at the start of the study, minimizing pre-existing differences between the groups that could affect the outcome of the experiment.

One Means That Researchers Use in Their Attempt to Make