Which of the following cell cycle phase transitions is most affected when the TP53 gene is lost or mutated?
A)G ? G01
B)G ? S1
C)G2 ? M
D)S ? G2

Question

Quizplus · Accepted Answer

The TP53 gene encodes the p53 protein, which is a crucial tumor suppressor involved in preventing cancer. It plays a significant role in the G1 checkpoint of the cell cycle, where it can halt the cell cycle in response to DNA damage or stress, allowing for repair or triggering apoptosis if the damage is irreparable. When TP53 is lost or mutated, cells can progress from G1 to S phase without proper DNA damage checks, leading to increased mutation rates and cancer development.

Which of the Following Cell Cycle Phase Transitions Is Most