In some proteins, the only transmembrane sequence is located C-terminally in the protein. These proteins are recognized by
A) the SRP.
B) the Sec61 translocon.
C) TRC40 (GET3).
D) the GET1-GET2 complex embedded in the ER membrane.

Question

Quizplus · Accepted Answer

DTRC40 (GET3) and the GET1-GET2 complex embedded in the ER membrane are involved in recognizing and inserting tail-anchored proteins, which have their transmembrane domain near the C-terminus, into the ER membrane.

In Some Proteins, the Only Transmembrane Sequence Is Located C-Terminally