Immediate hypersensitivity differs from delayed-type hypersensitivity in which one of the following ways? A) Immediate hypersensitivity is a CD4⁺ T cell-mediated disease. B) Immediate hypersensitivity does not require previous exposure to an antigen. C) Immediate hypersensitivity does not involve inflammation. D) Immediate hypersensitivity is driven by cytokines such as interleukin (IL)-4, IL-5, and IL-13. E) Immediate hypersensitivity typically leads to granuloma formation.

Question

Quizplus · Accepted Answer

In contrast to delayed-type hypersensitivity (DTH), which is a TH1-mediated disorder, immediate hypersensitivity is driven by cytokines, such as interleukin (IL)-4, IL-5, and IL-13, and is therefore a TH2-mediated disorder
Note that both types of hypersensitivity reactions involve CD4⁺ T cells (TH1 vs
TH2), although DTH also involves CD8⁺ T cells
Importantly, both types of hypersensitivity reactions occur only after prior exposure to an antigen, and they are both characterized by inflammation
Granuloma formation, as a chronic response to persistent microbes, is a pathologic feature more typical of DTH than immediate hypersensitivity.

Immediate Hypersensitivity Differs from Delayed-Type Hypersensitivity in Which One of the Following