Which of the following statements is TRUE regarding the role of NMDA receptors in mediating LTP in the brain?
A)NMDA receptors are critical to inducing LTP but not to maintaining LTP.
B)NMDA receptors block LTP in the brain unless magnesium ions are present.
C)NMDA receptors are depolarized by the binding of the neurotransmitter acetylcholine.
D)NMDA receptors create LTP by transporting magnesium ions from outside the cell into the cell.

Question

Quizplus · Accepted Answer

NMDA receptors are critical for inducing LTP but not for maintaining it. They are activated by the neurotransmitter glutamate and the co-agonist glycine, and their activation leads to the influx of calcium ions, which initiates a series of molecular events that result in strengthening of the synapse. However, once LTP has been established, it can be maintained without the continuous activation of NMDA receptors.

Which of the Following Statements Is TRUE Regarding the Role